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ANESTHETIC AND CARDIO-PULMONARY EFFECTS OF PROPOFOL OR ALFAXALONE WITH OR WITHOUT MIDAZOLAM CO-INDUCTION IN FENTANYL SEDATED DOGS

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Title: ANESTHETIC AND CARDIO-PULMONARY EFFECTS OF PROPOFOL OR ALFAXALONE WITH OR WITHOUT MIDAZOLAM CO-INDUCTION IN FENTANYL SEDATED DOGS
Author: Liao, PenTing
Department: Department of Clinical Studies
Program: Clinical Studies
Advisor: Sinclair, Melissa
Abstract: This thesis describes a prospective, randomized, incomplete Latin-square crossover, blind trial to investigate the effects of midazolam (M) as a co-induction agent in dogs induced and maintained with propofol (P) or alfaxalone (A) for diagnostic imaging. The quality of induction and recovery, induction and maintenance dose requirements for P or A, ease of maintenance using total intravenous anesthesia (TIVA), and cardio-pulmonary effects were determined in ten dogs assigned to P-S: P with saline (S); A-S: A with S; P-M: P with M; A-M: A with M. Fentanyl (7 µg kg-1, IV) was administered 10 minutes prior to an IV bolus of P (1 mg kg-1) or A (0.5 mg kg-1) followed by M (0.3 mg kg-1, IV) or S and additional boluses of P or A for intubation, followed by P or A TIVA during imaging. The induction quality was significantly better in A-M versus A-S, P-M versus P-S, and A-M versus P-S. The induction dose was significantly lower in P-M versus P-S, and A-M versus A-S. The TIVA rate with P-M was significantly lower than P-S but similar between A-M and A-S. Sedation, extubation and recovery quality, and TIVA duration were similar between treatments. Time to standing was significantly longer for A than P, but was similar within A or P treatments. After induction, heart rate (HR) was significantly higher in A-M than A-S and P-S. During imaging, HR of A-S and A-M were significantly higher than P-S. Before recovery, HR of A-M was significantly higher than P-S. Systolic blood pressure of A-S was significantly higher than A-M and P-M. There was no significant treatment difference for mean or diastolic blood pressure, cardiac index (CI), respiratory rate, occurrence of apnea, end-tidal CO2, and blood gas values. However, CI and HR significantly decreased after imaging compared to other phases. Midazolam improved the quality and reduced the required dose for both P and A induction, and reduced TIVA rate of P. There was no significant cardiopulmonary difference identified between treatments despite co-induction with M. The decrease in CI and HR after imaging warrants close monitoring during recovery.
URI: http://hdl.handle.net/10214/9991
Date: 2016-08
Rights: Attribution-NonCommercial-NoDerivs 2.5 Canada
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Attribution-NonCommercial-NoDerivs 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 2.5 Canada