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An investigation of the role of the TGFbeta-TAZ signaling crosstalk in canine osteosarcoma metastasis

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dc.contributor.advisor Viloria-Petit, Alicia Luu, Anita 2016-09-07T21:04:10Z 2016-09-07T21:04:10Z 2016-08 2016-08-22 2016-09-07
dc.description.abstract Osteosarcoma (OSA) is the most common bone tumor in canines and has high metastatic potential. Evidence suggests that TGFβ and TAZ, either independently or in combination, could potentially drive OSA progression. However, this role has not been explored in canine OSA. In this study, the prognostic value of TGFβ-TAZ signaling was explored in a tissue microarray. It was determined that the levels of active TGFβ signaling alone, or in combination with TAZ levels suggest an earlier time to metastasis. Furthermore, in vitro expression of metastasis-associated genes and cell migration following TAZ knockdown with/without TGFβ treatment was evaluated. In the absence of TGFβ and high levels of TAZ, cell migration was impaired in a metastatic OSA cell line, but not in two primary OSA cell lines. These findings suggest that TGFβ-TAZ signaling could have a role in promoting OSA metastasis. Additional studies are required to validate the importance of this crosstalk. en_US
dc.description.sponsorship OVC Pet Trust Fund en_US
dc.language.iso en en_US
dc.rights Attribution-NonCommercial-NoDerivs 2.5 Canada *
dc.rights.uri *
dc.subject TGFβ signaling en_US
dc.subject canine osteosarcoma en_US
dc.subject Metastasis en_US
dc.subject Hippo signaling en_US
dc.title An investigation of the role of the TGFbeta-TAZ signaling crosstalk in canine osteosarcoma metastasis en_US
dc.type Thesis en_US Biomedical Sciences en_US Master of Science en_US Department of Biomedical Sciences en_US
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Attribution-NonCommercial-NoDerivs 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 2.5 Canada