Main content

An investigation of the role of the TGFbeta-TAZ signaling crosstalk in canine osteosarcoma metastasis

Show full item record

Title: An investigation of the role of the TGFbeta-TAZ signaling crosstalk in canine osteosarcoma metastasis
Author: Luu, Anita
Department: Department of Biomedical Sciences
Program: Biomedical Sciences
Advisor: Viloria-Petit, Alicia
Abstract: Osteosarcoma (OSA) is the most common bone tumor in canines and has high metastatic potential. Evidence suggests that TGFβ and TAZ, either independently or in combination, could potentially drive OSA progression. However, this role has not been explored in canine OSA. In this study, the prognostic value of TGFβ-TAZ signaling was explored in a tissue microarray. It was determined that the levels of active TGFβ signaling alone, or in combination with TAZ levels suggest an earlier time to metastasis. Furthermore, in vitro expression of metastasis-associated genes and cell migration following TAZ knockdown with/without TGFβ treatment was evaluated. In the absence of TGFβ and high levels of TAZ, cell migration was impaired in a metastatic OSA cell line, but not in two primary OSA cell lines. These findings suggest that TGFβ-TAZ signaling could have a role in promoting OSA metastasis. Additional studies are required to validate the importance of this crosstalk.
URI: http://hdl.handle.net/10214/9968
Date: 2016-08
Rights: Attribution-NonCommercial-NoDerivs 2.5 Canada


Files in this item

Files Size Format View
Luu_Anita_201609_Msc.pdf 22.54Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record

Attribution-NonCommercial-NoDerivs 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 2.5 Canada