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Disturbed Object Processing in 5xFAD and 3xTG Mouse Models of Alzheimer's Disease: Going Beyond "Object Recognition"

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dc.contributor.advisor Winters, Boyer
dc.contributor.author Creighton, Samantha
dc.date.accessioned 2016-09-07T17:44:38Z
dc.date.available 2016-09-07T17:44:38Z
dc.date.copyright 2016-08
dc.date.created 2016-08-22
dc.date.issued 2016-09-07
dc.identifier.uri http://hdl.handle.net/10214/9952
dc.description.abstract Object recognition not a unitary process, and there are many uncharacterized facets of object processing that have relevance to Alzheimer’s disease (AD). To elucidate the specific nature of object processing deficits in transgenic mouse models of AD, we systematically evaluated performance on tasks that manipulate different types of object information: object identity (i.e., object recognition: OR), spatial processing (object location; OL), temporal processing (temporal order; TO), and multisensory perception (multisensory object oddity; MSO) in 12-month-old male and female 5xFAD and 3xTG mice. 5xFAD mice were impaired on OR, OL, TO and MSO. Conversely, 3xTG females had intact short-term OR, and when spatial cues were minimized both males and females had intact short-term OR. 3xTG mice had impaired OL, TO and MSO. Results reveal dissociations across AD strain, sex, and type of object processing, and should help to clarify the relationship between specific aspects of AD pathology and object-related information processing. en_US
dc.description.sponsorship Weston Brain Institute and NSERC en_US
dc.language.iso en en_US
dc.subject Object processing en_US
dc.subject Object recognition en_US
dc.subject Alzheimer's disease en_US
dc.subject 5xFAD en_US
dc.subject 3xTG en_US
dc.title Disturbed Object Processing in 5xFAD and 3xTG Mouse Models of Alzheimer's Disease: Going Beyond "Object Recognition" en_US
dc.type Thesis en_US
dc.degree.programme Psychology en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Psychology en_US


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