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The distribution and function of sea urchin histamine receptor 1 in larval Strongylocentrotus purpuratus

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dc.contributor.advisor Heyland, Andreas
dc.contributor.author Lutek, Keegan
dc.date.accessioned 2016-09-06T21:32:31Z
dc.date.available 2016-09-06T21:32:31Z
dc.date.copyright 2016
dc.date.created 2016-08-18
dc.date.issued 2016-09-06
dc.identifier.uri http://hdl.handle.net/10214/9936
dc.description.abstract In marine invertebrate complex life histories, planktonic larvae metamorphose into benthic juveniles that then develop into sexually mature adults. Hormonal or neurotransmitter-based signalling systems have evolved to regulate complex life histories and ensure settlement on the benthos and metamorphosis into juveniles occur after sufficient growth (i.e. metamorphic competence), in appropriate habitats. Modulators of metamorphic competence keep larvae prepared to settle and metamorphose until reception of a specific settlement cue. Histamine modulates metamorphic competence in Strongylocentrotus purpuratus; however, this signalling system is not fully understood. I determined the distribution and function of sea urchin histamine receptor 1 (suH1R) throughout S. purpuratus larval development. suH1R is found in the mouth and arm tips of larvae, and expression increases exponentially through development. Knockdown of suH1R leads to cell death in the arms. I suggest that suH1R inhibits apoptosis and/or maintains cell viability throughout larval development and may maintain metamorphic competence in S. purpuratus. en_US
dc.language.iso en en_US
dc.subject histamine en_US
dc.subject histamine receptor 1 en_US
dc.subject sea urchin en_US
dc.subject metamorphosis en_US
dc.subject cell death en_US
dc.title The distribution and function of sea urchin histamine receptor 1 in larval Strongylocentrotus purpuratus en_US
dc.type Thesis en_US
dc.degree.programme Integrative Biology en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Integrative Biology en_US
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