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Cyclooxygenase-2 expression in feline eyes with and without uveitis

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Title: Cyclooxygenase-2 expression in feline eyes with and without uveitis
Author: Sim, Zhi Hui
Department: Department of Clinical Studies
Program: Clinical Studies
Advisor: Pinard, Chantale
Abstract: Uveitis is one of the leading causes of blindness in cats, and an important potential therapeutic target is cyclooxygenase-2 (COX-2). This case-control study aimed to localize and quantify COX-2 expression in feline eyes with and without uveitis, and to further determine whether COX-2 expression correlates with the severity of uveitis. Diseased feline eyes were first histologically categorized as lymphocytic-plasmacytic uveitis, neutrophilic uveitis, and diffuse iris melanoma with or without uveitis. The severity of inflammation and COX-2 expression were scored in H&E and immuhistochemical-stained histologic sections, respectively. Uveal COX-2 expression was only detected in uveitic eyes although COX-2 expression was also identified in the cornea, conjunctiva, and vitreous chamber. Statistical analysis revealed significant positive correlation of uveal COX-2 expression with severity of uveitis, but no significant association of COX-2 expression with either therapy or sequelae. These data suggest that COX-2 may play a pathophysiologic role in feline uveitis.
Date: 2016-05
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