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The Anti-Inflammatory Effects of the Dietary Dipeptide, Gamma-Glutamylvaline in a Mouse Model of LPS-Induced Sepsis

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dc.contributor.advisor Mine, Yoshinori
dc.contributor.author Chee, MacKenzie
dc.date.accessioned 2016-05-02T14:03:16Z
dc.date.available 2016-05-02T14:03:16Z
dc.date.copyright 2016-04
dc.date.created 2016-04-19
dc.date.issued 2016-05-02
dc.identifier.uri http://hdl.handle.net/10214/9611
dc.description.abstract This study endeavored to identify the anti-inflammatory activity and signaling mechanism of the bioactive dietary dipeptide gamma-L-glutamyl-L-valine (γ-EV) via calcium-sensing receptor (CaSR) activation in a lipopolysaccharide (LPS)-induced mouse model of sepsis. Sepsis occurs when the otherwise tightly-regulated immune and inflammatory response that eliminates invading pathogens and repairs injured tissues, switches to an uncontrolled response that causes an acute life-threatening inflammatory syndrome. γ-EV had anti-inflammatory activity in BALB/c mice with LPS-induced sepsis as measured by the reduction of the pro-inflammatory cytokines TNF-α, IL-6, and IL-1β in plasma and small intestine tissue. There was a γ-EV-mediated decrease in the phosphorylation of the downstream signaling proteins JNK and IκBα in small intestine tissue, which indicates γ-EV likely has an effect on an upstream signaling protein common to both the AP-1 and NF-κB pathways. The study proposes that a direct interaction of CaSR-recruited β-arrestin2 with TRAF6, TAB1, and IκBα constitutes γ-EV’s anti-inflammatory activity in LPS-induced inflammation. This study provides evidence that γ-EV has health-promoting activity. en_US
dc.description.sponsorship Advanced Foods and Materials Network (AFMNet), Natural Sciences and Engineering Research Council of Canada (NSERC) en_US
dc.language.iso en en_US
dc.title The Anti-Inflammatory Effects of the Dietary Dipeptide, Gamma-Glutamylvaline in a Mouse Model of LPS-Induced Sepsis en_US
dc.type Thesis en_US
dc.degree.programme Food Science en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Food Science en_US
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