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The Effect of Acute and Chronic High Fructose Corn Syrup Pre-exposure on Naltrexone-Induced Conditioned Place Aversion

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dc.contributor.advisor Leri, Francesco
dc.contributor.author Daniels, Stephen
dc.date.accessioned 2015-06-05T18:54:58Z
dc.date.available 2015-06-05T18:54:58Z
dc.date.copyright 2015-06
dc.date.created 2015-06-03
dc.date.issued 2015-06-05
dc.identifier.uri http://hdl.handle.net/10214/8889
dc.description.abstract Withdrawal is a major component of addiction. Antagonism of mu-opioid receptors (MOR) results in withdrawal following ingestion of sugars and drugs of abuse. We hypothesize that naltrexone (NTX) will precipitate affective withdrawal following ingestion of HFCS. Affective withdrawal was assessed using conditioned place avoidance (CPA). Food restriction was employed to investigate the effects of increased HFCS consumption. In a separate experiment intragastric infusions of HFCS will be given prior to NTX conditioning. Effects will be compared with CPA after acute and chronic heroin. NTX-induced a CPA in naïve animals regardless of HFCS exposure. Increased HFCS consumption resulted in NTX-induced CPA with both intragastric administration and food restriction, not seen with 0% HFCS. A significant CPA was observed after acute and chronic heroin administration, which was greater than control animals. Therefore, NTX failed to precipitate an affective withdrawal after pre-exposure to HFCS that was comparable with heroin. en_US
dc.description.sponsorship This research was funded by grants from the Ontario Brain Institute, Integrated Discovery program: Canadian Biomarker Integration Network for Depression (CAN-BIND) en_US
dc.language.iso en en_US
dc.subject High Fructose Corn Syrup en_US
dc.subject Naltrexone en_US
dc.subject Conditioned Place Avoidance en_US
dc.subject Heroin en_US
dc.title The Effect of Acute and Chronic High Fructose Corn Syrup Pre-exposure on Naltrexone-Induced Conditioned Place Aversion en_US
dc.type Thesis en_US
dc.degree.programme Psychology en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Psychology en_US
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