Main content

Accuracy and Safety of Image Guided Percutaneous Injection of Gelified Ethanol (Discogel®) in the Intervertebral Disc in Dogs

Show simple item record

dc.contributor.advisor Chalmers, Heather
dc.contributor.author Mackenzie, Shawn
dc.date.accessioned 2015-06-04T18:19:28Z
dc.date.available 2015-06-04T18:19:28Z
dc.date.copyright 2015-05
dc.date.created 2015-04-17
dc.date.issued 2015-06-04
dc.identifier.uri http://hdl.handle.net/10214/8885
dc.description.abstract Accuracy of image guided injection of the intervertebral discs and the distribution and safety of a gelified ethanol product was investigated in two phases. In the first phase, the ability to accurately perform percutaneous injection of gelified ethanol into intervertebral discs of cadaver dogs using three imaging modalities was evaluated (n=14). Injections were performed at random sites along the vertebral column (n=78 discs). Systematic dissection was performed to confirm the location of the injected preparation. The material was successfully delivered to the nucleus pulposus in 55 of 78 (71%) intervertebral discs. Forty-nine of 78 (63%) injections had leakage of the injected material including 10 (13%) with material in the vertebral canal. The success of injections did not differ by site (p=0.9337) or body weight (p=0.3273). The odds of a successful injection without significant leakage were 12 times higher when using computed tomography (CT) compared to ultrasound (p=0.0026), and trended towards significantly higher with CT than fluoroscopy (p=0.0620). In the second phase, the feasibility of image guided injection developed in phase I was tested in 10 healthy dogs at the lumbosacral disc. Successful injection of the gelified ethanol was achieved in all 10 dogs, with material evident in the vertebral canal in 4 dogs. Short-term (n=10) and long-term (n=5) follow-up CT and magnetic resonance imaging (MRI) as well as neurological examinations were used to evaluate the effects of the injection. All dogs tolerated the injection well; there were no clinical adverse reactions noted over the study period. The long term follow up CT and MRI studies revealed a static appearance in 3 of 5 dogs with evidence of redistribution of the injected preparation in 2 of 5 dogs. In conclusion, percutaneous injection of the intervertebral discs is achievable with multiple imaging modalities but is most accurate using CT guidance. Injection of gelified ethanol into the lumbosacral disc of healthy dogs is well tolerated with no adverse effects noted, even with mild leakage of material from the disc. This work provides a solid foundation for the development of this technique as a potential treatment option for dogs with intervertebral disc protrusions. en_US
dc.description.sponsorship Ontario Veterinary College Pet Trust Fund, American College of Veterinary Radiologist en_US
dc.language.iso en en_US
dc.rights Attribution-NonCommercial-NoDerivs 2.5 Canada *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/2.5/ca/ *
dc.subject dogs en_US
dc.subject intervertebral disc en_US
dc.subject herniation en_US
dc.subject protrusion en_US
dc.subject disc injection en_US
dc.subject minimally invasive en_US
dc.subject gelified ethanol en_US
dc.subject discogel en_US
dc.title Accuracy and Safety of Image Guided Percutaneous Injection of Gelified Ethanol (Discogel®) in the Intervertebral Disc in Dogs en_US
dc.type Thesis en_US
dc.degree.programme Clinical Studies en_US
dc.degree.name Doctor of Veterinary Science en_US
dc.degree.department Department of Clinical Studies en_US
dc.rights.license All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.


Files in this item

Files Size Format View
Mackenzie_Shawn_201506_DVSC.pdf 3.273Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 2.5 Canada