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Physico-chemical and computational studies of bacterial carbohydrates

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dc.contributor.advisor Monteiro, Mario Valliani, Moez 2015-05-15T15:37:44Z 2016-05-11T05:00:20Z 2015-05 2015-05-11 2015-05-15
dc.description.abstract This thesis is composed of two investigations: the structure of the capsular polysaccharide expressed on the surface of Clostridium perfringens strain 1395 and the Clostridium bolteae capsular polysaccharide conformation by molecular modelling. The majority of gas gangrene development is due to Clostridium perfringens. Clostridium bolteae was found present in the intestinal tract of children diagnosed with autism and not present in the control group. Developing a vaccine by targeting the capsular polysaccharide of virulent strains will help prevent the development of these detrimental infections. However, in order to produce a vaccine, the structure of the capsular polysaccharide must first be determined. The Clostridium perfringens capsular polysaccharide has yet to be fully characterized but has been found thus far to be an oligosaccharide repeat unit containing →4)-β-D-Glc-(1→3)-D-Gal(1→, →2)-[β-D-Glc-(1→3)]-α-D-Gal-(1→, →4)-α-D-GalNAc-(1→ and →3)-[β-D-Glc-(1→2)]-β-D-Man-(1→. The conformation of the Clostridium bolteae polysaccharide was found to be a right-handed seven-unit repeating helix. en_US
dc.language.iso en en_US
dc.subject Clostridium perfringens en_US
dc.subject Clostridium bolteae en_US
dc.subject capsular polysaccharide en_US
dc.subject cps en_US
dc.subject computer modelling en_US
dc.title Physico-chemical and computational studies of bacterial carbohydrates en_US
dc.type Thesis en_US Chemistry en_US Master of Science en_US Department of Chemistry en_US
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