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The metabolism of androstenone and other steroid hormone conjugates in relation to boar taint

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Title: The metabolism of androstenone and other steroid hormone conjugates in relation to boar taint
Author: Laderoute, Heidi
Department: Department of Animal and Poultry Science
Program: Animal and Poultry Science
Advisor: Squires, James
Abstract: Increased public interest in the welfare of pigs reared for pork production has led to an increased effort in finding new approaches for controlling the unpleasant odour and flavour from heated pork products known as boar taint. Therefore, this study investigated the metabolism of androstenone and the enzymes involved in its sulfoconjugation in order to further understand the pathways and genes involved in the development of this meat quality defect. Leydig cells that were incubated with androstenone produced 3-keto-sulfoxy-androstenone, providing direct evidence, for the first time, that sulfoconjugation of this steroid does occur in the boar. In addition, human embryonic kidney cells that were overexpressed with porcine sulfotransferase (SULT) enzymes showed that SULT2A1, but not SULT2B1, was responsible for sulfoconjugating androstenone. These findings emphasize the importance of conjugation in steroid metabolism and its relevance to boar taint is discussed.
URI: http://hdl.handle.net/10214/8837
Date: 2015-04
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