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Vasodilators Produced during Skeletal Muscle Contraction Influence One Another’s Ability to Elicit Vasodilation

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Title: Vasodilators Produced during Skeletal Muscle Contraction Influence One Another’s Ability to Elicit Vasodilation
Author: Lamb, Iain
Department: Department of Human Health and Nutritional Sciences
Program: Human Health and Nutritional Sciences
Advisor: Murrant, Coral
Abstract: Pharmacological inhibitions of vasodilators produced during exercise suggest that no single vasodilator is obligatory in mediating active hyperaemia. Therefore, vasodilators may interact to compensate and mask the loss of one another. Thus, we aimed to investigate if interaction(s) exist between vasodilators potassium (K+), nitric oxide (NO) and adenosine (ADO). To identify interactions we applied vasodilators in the absence and presence of one another on the transverse arteriole of the hamster cremaster muscle in situ. By measuring change in vessel diameter we assessed the magnitude of vasodilation elicited by a combination of vasodilators compared to when each were applied alone. Results show physiological concentrations of K+ blunt the magnitude of dilation produced by NO and ADO by altering inwardly rectifying potassium channels and Na+/K+-ATPase activity. The significance is that vasodilators interact to influence one another’s dilatory ability offering a potential explanation as to why an obligatory vasodilatory has not been identified.
URI: http://hdl.handle.net/10214/8687
Date: 2014-12
Rights: Attribution-NoDerivs 2.5 Canada
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Attribution-NoDerivs 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NoDerivs 2.5 Canada