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An Investigation of the Barrier Properties and pH Dependent Permeability of Scaffolded Vesicles

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dc.contributor.advisor Lipkowski, Jacek
dc.contributor.author Conlon, Shannon
dc.date.accessioned 2015-01-06T19:58:48Z
dc.date.available 2015-01-06T19:58:48Z
dc.date.copyright 2014-12
dc.date.created 2014-12-17
dc.date.issued 2015-01-06
dc.identifier.uri http://hdl.handle.net/10214/8665
dc.description.abstract Nutraceutical carriers rely on multiple features, including permeability and biocompatibility, in order to function properly. The scaffolded vesicle, which was recently proposed, has been able to incorporate these features. The scaffolded vesicle was composed of a hydrogel core and a lipid membrane coating. The composition of the coating can be altered for specific functions. The focus of this project was to incorporate charged lipids to investigate the pH dependent permeability of the scaffolded vesicle. The incorporation of various amounts of myristic acid resulted in a variation in permeability below the pKa, but little change above the pKa. The incorporation of 4-hexylaniline, increased permeability at all compositions investigated. When 4-tetradecylaniline was incorporated at various amounts, the permeability was constant below the pKa, while permeability decreased with increased amount above the pKa value. en_US
dc.language.iso en en_US
dc.subject vesicle en_US
dc.subject DMPC en_US
dc.subject membrane en_US
dc.subject drug delivery en_US
dc.subject scaffolded vesicle en_US
dc.subject cholesterol en_US
dc.title An Investigation of the Barrier Properties and pH Dependent Permeability of Scaffolded Vesicles en_US
dc.type Thesis en_US
dc.degree.programme Chemistry en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Chemistry en_US


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