Main content

An Investigation of the Barrier Properties and pH Dependent Permeability of Scaffolded Vesicles

Show full item record

Title: An Investigation of the Barrier Properties and pH Dependent Permeability of Scaffolded Vesicles
Author: Conlon, Shannon
Department: Department of Chemistry
Program: Chemistry
Advisor: Lipkowski, Jacek
Abstract: Nutraceutical carriers rely on multiple features, including permeability and biocompatibility, in order to function properly. The scaffolded vesicle, which was recently proposed, has been able to incorporate these features. The scaffolded vesicle was composed of a hydrogel core and a lipid membrane coating. The composition of the coating can be altered for specific functions. The focus of this project was to incorporate charged lipids to investigate the pH dependent permeability of the scaffolded vesicle. The incorporation of various amounts of myristic acid resulted in a variation in permeability below the pKa, but little change above the pKa. The incorporation of 4-hexylaniline, increased permeability at all compositions investigated. When 4-tetradecylaniline was incorporated at various amounts, the permeability was constant below the pKa, while permeability decreased with increased amount above the pKa value.
URI: http://hdl.handle.net/10214/8665
Date: 2014-12


Files in this item

Files Size Format View
Conlon_Shannon_201412_Msc.pdf 2.868Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record