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Surface Analytical Studies of Gramicidin A in Biomimetic Model Membrane Systems

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dc.contributor.advisor Lipkowski, Jacek
dc.contributor.author Goodall, Barbara Lynn
dc.date.accessioned 2014-12-24T18:17:29Z
dc.date.available 2014-12-24T18:17:29Z
dc.date.copyright 2014-12
dc.date.created 2014-12-12
dc.date.issued 2014-12-24
dc.identifier.uri http://hdl.handle.net/10214/8635
dc.description.abstract This thesis is an investigation of the properties of gramicidin A in model membrane systems. This study investigates a solid supported bilayer lipid membrane comprised of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and gramicidin A deposited on a thioglucose modified Au(111) electrode. A “floating” bilayer lipid membrane was also investigated that was composed of DMPC, cholesterol, glycolipid monosialoganglioside (GM1), and gramicidin A deposited on a thioglucose modified Au(111) electrode. The GM1 was used as a spacer molecule to create a water reservoir between the modified electrode and lipid bilayer. Polarization modulation infrared reflection adsorption spectroscopy (PM-IRRAS) was used to investigate the solid supported and the floating bilayer lipid membrane. The PM-IRRAS studies were completed to probe the electric field driven changes in the orientation and conformation of gramicidin A in the lipid bilayer. Atomic force microscopy was used to investigate the topography and thickness of the floating bilayer lipid membrane system. en_US
dc.description.sponsorship NSERC en_US
dc.language.iso en en_US
dc.subject gramicidin en_US
dc.subject PM-IRRAS en_US
dc.subject AFM en_US
dc.subject model membrane en_US
dc.title Surface Analytical Studies of Gramicidin A in Biomimetic Model Membrane Systems en_US
dc.type Thesis en_US
dc.degree.programme Chemistry en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Chemistry en_US
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