Main content

Role of Chronic Cocaine Exposure and PFC Lesion in the Induction of Perseverative Responding

Show full item record

Title: Role of Chronic Cocaine Exposure and PFC Lesion in the Induction of Perseverative Responding
Author: Allen, Craig
Department: Department of Psychology
Program: Psychology
Advisor: Leri, Francesco
Abstract: One of the central characteristics of pathological gambling ( perseverative responding. Perseverative responding is the repetition of a previously appropriate response in a manner, or context, which is detrimental to the individual. While several studies have shown a link between perseverative responding and disruption of prefrontal cortex ( unclear whether these factors are causally related to perseveration. The aim of the current studies was to establish a causal relationship between perseverative responding and either PFC dysfunction or cocaine exposure, as well as to characterize the nature of the impairment. Using a novel experimental procedure which isolated aspects of behaviour, rats were assessed for perseverative responding following chronic cocaine exposure or lesions to subregions of the PFC. Results from these experiments, and existing literature, suggest the existence of at least three distinct types of perseveration. Chronic cocaine exposure was found to induce all three types of perseveration, while the effect of PFC lesions was more selective with different regions associated with different forms of perseveration. Perhaps the most relevant of these for PG are lesions to the medial PFC, which produced perseveration by impairing animals’ ability to alter behaviour to avoid punishment. These studies advance our understanding of an important aspect of PG and addiction and help to clarify some discrepencies in existing literature.
Date: 2014-09
Terms of Use: All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.

Files in this item

Files Size Format View Description
Allen_Craig_201411_PhD.pdf 1.488Mb PDF View/Open Thesis

This item appears in the following Collection(s)

Show full item record