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Antagonizing Dorsal Hippocampal Dopamine D1-type Receptors Affects Social Learning and Social Interactions but not Food Intake in Male and Female Mice

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dc.contributor.advisor Choleris, Elena
dc.contributor.author Matta, Richard
dc.date.accessioned 2014-10-23T19:26:28Z
dc.date.available 2014-10-23T19:26:28Z
dc.date.copyright 2014-10
dc.date.created 2014-10-16
dc.date.issued 2014-10-23
dc.identifier.uri http://hdl.handle.net/10214/8524
dc.description.abstract Dopamine (DA) is involved in many motivationally relevant behaviors, including social learning, feeding, and social interactions. With systemic treatments, our lab has previously found an involvement of DA D1-type receptors in the social transmission of food preferences (STFP; Choleris et al., 2011), however, the site(s) of action remain unknown. The ventral tegmental area has dopaminergic projections to the hippocampus—a site important for social learning in the STFP. In this study, we microinfused the DA D1-type receptor antagonist SCH23390 into the dorsal hippocampus of adult male and female mice. We found that SCH23390 blocked social learning in both male and female mice without influencing total food intake. While there was a sex-specific effect of SCH23390 on certain social behaviors, there was no significant influence of drug treatment on oronasal investigation, or olfactory discrimination, for either sex. Thus, hippocampal DA D1-type receptors may play an important role in the ‘social brain’. en_US
dc.description.sponsorship NSERC en_US
dc.language.iso en en_US
dc.rights Attribution-NonCommercial 2.5 Canada *
dc.rights.uri http://creativecommons.org/licenses/by-nc/2.5/ca/ *
dc.subject D1-type receptors en_US
dc.subject SCH23390 en_US
dc.subject hippocampus en_US
dc.subject CA1 en_US
dc.subject social transmission en_US
dc.subject social learning en_US
dc.subject feeding en_US
dc.subject dopamine receptor en_US
dc.subject estrous cycle en_US
dc.subject mice en_US
dc.subject sex differences en_US
dc.subject STFP en_US
dc.subject social behavior en_US
dc.subject dopamine en_US
dc.title Antagonizing Dorsal Hippocampal Dopamine D1-type Receptors Affects Social Learning and Social Interactions but not Food Intake in Male and Female Mice en_US
dc.type Thesis en_US
dc.degree.programme Psychology en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Psychology en_US
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Attribution-NonCommercial 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NonCommercial 2.5 Canada