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Myocardial Remodelling and Dysfunction in the Pathogenesis of Heart Failure

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Title: Myocardial Remodelling and Dysfunction in the Pathogenesis of Heart Failure
Author: Huber, Jason
Department: Department of Human Health and Nutritional Sciences
Program: Human Health and Nutritional Sciences
Advisor: Simpson, Jeremy
Abstract: This thesis is an investigation of myocardial remodelling and dysfunction in the pathogenesis of the Transverse Aortic Constriction (TAC) and Myocardial Infarction (MI) models of heart failure. The analysis of animal models of heart failure is generally limited to a single time point and in the ventricle of the inciting stress with the opposing ventricle largely ignored. To further our understanding of the TAC and MI models, invasive hemodynamic, morphometric, histological, and molecular analysis were performed at 2, 4, 9, and 18 weeks post-surgical intervention in the left and right ventricles. In both models, our data demonstrated: 1) significant right ventricular remodelling acutely following intervention; 2) no correlation between left ventricular end diastolic pressure and fibrosis; 3) concentric and eccentric hypertrophy occurred independently of hemodynamic stresses in the left and right ventricles. These data contributes to our knowledge of cardiac remodelling and dysfunction in the progression of heart failure.
URI: http://hdl.handle.net/10214/8104
Date: 2014-05


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