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Comparison of recurrent and sporadic Clostridium difficile infection and microbiological investigation of response of recurrent Clostridium difficile infection to fecal microbiota transplantation

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dc.contributor.advisor Bersenas, Alexa
dc.contributor.advisor Weese, Scott
dc.contributor.advisor Kim, Peter
dc.contributor.author Richardson, Connor
dc.date.accessioned 2014-05-05T18:20:14Z
dc.date.available 2014-05-05T18:20:14Z
dc.date.copyright 2014-04
dc.date.created 2014-04-23
dc.date.issued 2014-05-05
dc.identifier.uri http://hdl.handle.net/10214/8044
dc.description.abstract This thesis investigates the strain distribution and characteristics of Clostridium difficile recovered from patients with sporadic and recurrent diarrhea. Samples were collected from patients with both recurrent and sporadic disease and ribotyping was conducted to determine the strain distribution, in particular examining the prevalence of NAP1/027. Antimicrobial susceptibility to vancomycin and metronidazole was determined using E-tests. It was found that both gender (female) and NAP1/027 were positively associated with recurrent disease. For patients undergoing human biotherapy for treatment of recurrent disease, pre and post-treatment samples were ribotyped. It was found that NAP1/027 was present in high proportions in individuals after clinical cure, however, no association was determined between the presence of C. difficile and response to fecal microbiota transplantation (FMT)treatment. en_US
dc.description.sponsorship Canadian Institutes of Health Research (CIHR) and the Natural Sciences and Engineering Research Council (NSERC) Collaborative Health Research Projects (project 413548-2012) en_US
dc.language.iso en en_US
dc.subject Clostridium difficile en_US
dc.subject C. difficile en_US
dc.subject CDI en_US
dc.subject Sporadic en_US
dc.subject Recurrent en_US
dc.subject Fecal Microbiota Transplant en_US
dc.subject ribotyping en_US
dc.subject NAP1/027 en_US
dc.title Comparison of recurrent and sporadic Clostridium difficile infection and microbiological investigation of response of recurrent Clostridium difficile infection to fecal microbiota transplantation en_US
dc.type Thesis en_US
dc.degree.programme Clinical Studies en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Clinical Studies en_US
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