Main content

Evaluating the role of Nck adaptor proteins in the endothelial to mesenchymal transition

Show full item record

Title: Evaluating the role of Nck adaptor proteins in the endothelial to mesenchymal transition
Author: Harris, Cameron; Jones, Nina
Department: Department of Molecular and Cellular Biology
Program: Molecular and Cellular Biology
Advisor: Jones, Nina
Abstract: The formation of a functional cardiovascular system depends on a collection of cells undergoing a coordinated endothelial to mesenchymal transition (EnMT) during development. This EnMT is responsible for providing the septations and valves of the mature heart, with defects causing congenital heart malformations. The Nck family of adaptor proteins has previously been linked to heart development, with indications it is through this EnMT process. By measuring well characterized markers of EnMT in a developmental mouse model, and establishing an endothelial cell line, the mechanism behind EnMT signaling in heart development can begin to be elucidated. Understanding the role of Nck in EnMT will provide new insights into the pathways involved in the mesenchymal transition in heart development and extrapolated further to pathological processes utilizing EnMT such as organ and tissue fibrosis.
URI: http://hdl.handle.net/10214/7768
Date: 2013-12
Terms of Use: All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.


Files in this item

Files Size Format View
Harris_Cameron_201312_Msc.pdf 2.617Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record