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The effect of butter, naturally enriched with trans-10, cis-12 conjugated linoleic acid, on insulin resistance and inflammation in high fat-fed rodents

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Title: The effect of butter, naturally enriched with trans-10, cis-12 conjugated linoleic acid, on insulin resistance and inflammation in high fat-fed rodents
Author: Stefanson, Amanda L
Department: Department of Human Health and Nutritional Sciences
Program: Human Health and Nutritional Sciences
Advisor: Wright, David C
Abstract: This study was conducted to evaluate dietary trans-10, cis-12 conjugated linoleic acid (t10, c12-CLA), given the studies showing that supplemental doses has a negative impact on insulin resistance. To that end, we produced a 60% high fat diet composed of butter produced from milk collected from dairy cows suffering from subacute ruminal acidosis (SARA) – a condition that can sometimes result from the dairy industry production practice of feeding a high grain, low forage diet to milk-producing cows. This butter represents the most t10, c12-CLA-enriched source of naturally occurring t10, c12-CLA for humans. We compared the effects of the high t10, c12-CLA butter against a commercially available butter in a high fat diet-induced rodent model of insulin resistance. After 8 weeks, whole body glucose homeostasis was evaluated along with markers of inflammation, indicated by mitogen-activated protein kinase (MAPK) activation.
URI: http://hdl.handle.net/10214/7545
Date: 2013-09
Rights: Attribution-NonCommercial-NoDerivs 2.5 Canada
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Attribution-NonCommercial-NoDerivs 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 2.5 Canada