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Investigation of growth performance and immunomodulatory factors associated with the hepatic gene expression of the insulin-like growth factor system in nursery pigs

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dc.contributor.advisor Friendship, Robert
dc.contributor.author Slifierz, Mackenzie
dc.date.accessioned 2013-09-06T21:10:25Z
dc.date.available 2013-09-06T21:10:25Z
dc.date.copyright 2013-08
dc.date.created 2013-08-27
dc.date.issued 2013-09-06
dc.identifier.uri http://hdl.handle.net/10214/7475
dc.description.abstract The insulin-like growth factor (IGF) system is an important determinant of growth in animals and recent findings suggest that immunomodulatory activity may regulate the IGF system independent of nutritional parameters. A cross-sectional study of the hepatic gene expression of the IGF system (IGF-1, IGFBP-3, GHR) and immunomodulatory agents (CRP, Hp, SAA, IL-1β, IL-6, IL-10, IL-18, IFN-α, IFN-γ, TNF-α) in nursery pigs (n=168) from 8 farms was completed. Production parameters and swine pathogens (Salmonella spp., L. intracellularis, Brachyspira spp., ETEC, MRSA, SIV, and PRRSV) were also assessed in relation to the IGF system. Hepatic expression of IGF-1, IGFBP-3, and GHR was associated with growth performance and was inversely associated with several immunomodulatory agents including Hp, SAA, IL-1β, IL-18, and TNF-α. These findings suggest that elevated levels of proinflammatory agents may dysregulate the transcriptional expression of the IGF system in hepatic tissue and consequently affect the growth and metabolism of nursery pigs. en_US
dc.description.sponsorship Swine Innovation Porc en_US
dc.language.iso en en_US
dc.rights Attribution-NonCommercial 2.5 Canada *
dc.rights.uri http://creativecommons.org/licenses/by-nc/2.5/ca/ *
dc.subject pig en_US
dc.subject immunology en_US
dc.subject ADG en_US
dc.subject IGF en_US
dc.subject epidemiology en_US
dc.title Investigation of growth performance and immunomodulatory factors associated with the hepatic gene expression of the insulin-like growth factor system in nursery pigs en_US
dc.type Thesis en_US
dc.degree.programme Population Medicine en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Population Medicine en_US
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Attribution-NonCommercial 2.5 Canada Except where otherwise noted, this item's license is described as Attribution-NonCommercial 2.5 Canada