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Prospective Evaluation of the Epidemiology and Microbiology of Surgical Site Infections

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Title: Prospective Evaluation of the Epidemiology and Microbiology of Surgical Site Infections
Author: Turk, Ryen
Department: Department of Pathobiology
Program: Pathobiology
Advisor: Weese, Scott
Abstract: Surgical site infections (SSIs) are an emerging cause of increased morbidity, mortality, and treatment cost, in veterinary medicine. Medical records were searched to evaluate for associations that could increase the risk of developing SSIs. Logistic regression was used to analyze the risk factors statistically, to determine their influence on SSI risk. An SSI incidence rate of 3.0% was found in this study for all small animal surgical procedures performed from September 2010 to July 2011, with implants, hypotension and surgical classification associated with increased likelihood of SSI. Active surveillance is crucial for the development of methods to prevent SSI’s. Biofilms contribute to the antimicrobial resistance properties commonly found in bacteria such as methicillin-resistant Staphylococcus pseudintermedius, which is found in canines. An enzyme known as DispersinB was studied to assess its effect on biofilm formation and degradation. DispersinB prevented the formation and eradicated biofilm in vitro. In vivo testing is required to further assess the effects of DispersinB.
URI: http://hdl.handle.net/10214/7431
Date: 2013-08


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