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A Diagnostic Target Against Clostridium bolteae, Towards a Multivalent Vaccine for Autism-Related Gastric Bacteria

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dc.contributor.advisor Monteiro, Mario
dc.contributor.author Pequegnat, Brittany
dc.date.accessioned 2013-08-16T14:52:23Z
dc.date.available 2013-08-16T14:52:23Z
dc.date.copyright 2013-08
dc.date.created 2013-08-09
dc.date.issued 2013-08-16
dc.identifier.uri http://hdl.handle.net/10214/7375
dc.description.abstract Constipation and diarrhea are common in autistic patients. Antibiotic treatment against bacteria appears to partially alleviate autistic-related symptoms. The bacterium Clostridium bolteae has been shown to be overabundant in the intestinal tract of autistic children suffering from gastric intestinal ailments, and as such is an organism that could potentially aggravate gastrointestinal symptoms. Investigation of the cell-wall polysaccharides of C. bolteae was employed in order to evaluate their structure and immunogenicity. Exploration revealed that C. bolteae produces a conserved specific capsular polysaccharide comprised of rhamnose and mannose units: [->3)-α-D-Manp-(1->4)-β-D-Rhap-(1->], which is immunogenic in rabbits. This is the first described immunogen of C. bolteae and indicates the prospect of using this polysaccharide as a vaccine to reduce or prevent colonization of the intestinal tract in autistic patients, and as a diagnostic marker for rapid detection. This diagnostic target can be used in a multivalent vaccine, which may potentially include Sutterella and Desulfovibrio. en_US
dc.language.iso en en_US
dc.subject Autism en_US
dc.subject Polysaccharide en_US
dc.subject Clostridium bolteae en_US
dc.subject Conjugate Vaccine en_US
dc.subject Immunogen en_US
dc.title A Diagnostic Target Against Clostridium bolteae, Towards a Multivalent Vaccine for Autism-Related Gastric Bacteria en_US
dc.type Thesis en_US
dc.degree.programme Chemistry en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Chemistry en_US
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