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The influence of Toll-like receptors on murine invariant natural killer T cell activation

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Title: The influence of Toll-like receptors on murine invariant natural killer T cell activation
Author: Villanueva, Alexander Ian
Department: Department of Pathobiology
Program: Pathobiology
Advisor: Sharif, Shayan
Abstract: Invariant natural killer T (iNKT) cells are a versatile subclass of T lymphocytes which recognize glycolipid antigens. iNKT cells are capable of rapidly producing a broad array of cytokines in response to stimulation; thus, they play an important role in the early regulation of a variety of immune responses. It was hypothesized that iNKT cells express functional Toll-like receptors (TLRs) and that stimulation of TLRs by their ligands modulates iNKT cells responses. In the first objective, it was revealed that upon stimulation with anti-CD3 monoclonal antibody and interferon (IFN)-α, expression of TLRs was enhanced in iNKT cells. Furthermore, stimulation of iNKT cells with TLR ligands led to a significant increase in the expression of several cytokines. In the second objective, the mechanisms behind the modulatory effects of the TLR9 ligand (CpG-ODN) on iNKT cells were determined. Altogether, these findings suggest a direct role for TLRs in iNKT cell activation.
URI: http://hdl.handle.net/10214/7252
Date: 2013-06


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