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Single mutation can affect antibody’s ability to bind to and neutralize bovine herpes virus

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Title: Single mutation can affect antibody’s ability to bind to and neutralize bovine herpes virus
Author: Koti, M.; Nagy, E.; Kaushik, A.K.; Institute for Community Engaged Scholarship
Abstract: Genetically engineered antibody fragments, working either individually or in pairs, were able to effectively bind to and neutralize bovine herpes virus type-1 in infected cells. A single mutation affected the antibody fragment’s ability to neutralize the virus, without changing its ability to recognize and attach to it.
Description: This summary is a project of the Institute for Community Engaged Scholarship (ICES) at the University of Guelph, with project partners: the Catalyst Centre, SPARK Program at the University of Guelph, and Knowledge Mobilization Unit at York University. This project is part of the Pan-Canadian Research Impact Network. http://csahs.uoguelph.ca/pps/Clear_Research
URI: http://hdl.handle.net/10214/5653
Date: 2013-03-06


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