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A STUDY OF THE GENESIS 0F RHABDOMYOSARCOMAS INDUCED WITH NICKEL SULFIDE IN THE RAT

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Title: A STUDY OF THE GENESIS 0F RHABDOMYOSARCOMAS INDUCED WITH NICKEL SULFIDE IN THE RAT
Author: Herchen, Heinrich Herchen
Abstract: Investigations carried out by Hueper (1955, 1957, 1958) and Hueper and Payne (1959) have contributed to our present knowledge of the cancerogenecity of metals and their role as occupational hazards, particularly in respect to lung cancer. Hueper considers arsenic, asbestos, chromium and nickel to be established metallurgical carcinogens. Besides epidemiological investigations, Hueper and co-workers administered various forma of chromium and nickel parenterally and powdered metallic nickel by inhalation in their studies of metal cancerigenesis. Cobalt was reported by Heath (1954, 1956) to be a potent carcinogen in rats with rhabdomyosarcomas amongst the neoplasms observed following intramuscular injection. Gillman and Ruckebauer (1962) confirmed these findings and stressed the high proportion of a "type of sarcoma that is clearly of muscle origin". They found that mice did not respond at all to this cancerigenic stimulus, a fact also noted by Heath (1959). Gilman (1962) showed in later work that nickel sulfide and oxide and the corresponding cobalt compounds were cancerigenic in rats on intramuscular injection. Again a very high percentage of the cobalt and nickel-induced tumours were rhabdomyosarcomas. However, the soluble nickel...
Description: A thesis submitted in partial fulfillment of the requirements for the Degree of Master of Veterinary Science to the School of Graduate Studies, University of Toronto, 1963
URI: http://hdl.handle.net/10214/5413
Date: 1963
Rights: This work may be protected by copyright laws and is provided for educational and research purposes only. If you believe you are the rights holder and object to the University of Guelph's use of this document, please contact libair@uoguelph.ca.


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