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The Effects of Cooked Whole Asparagus (Asparagus officinalis L.) and its Purified Bioactive, Rutin, on Symptoms of DSS-induced Acute Colitis and Recovery in C57BL/6 Mice

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dc.contributor.advisor Lindsay, Robinson
dc.contributor.author Lu, Jenifer Thi
dc.date.accessioned 2013-01-17T19:26:48Z
dc.date.available 2013-05-01T05:00:20Z
dc.date.copyright 2013-01
dc.date.created 2013-01-14
dc.date.issued 2013-01-17
dc.identifier.uri http://hdl.handle.net/10214/5330
dc.description.abstract This thesis explored the effects of cooked whole asparagus and its purified bioactive, rutin, on colitis symptoms and disease progression in mice using a chemically-induced model of colitis. This model mimics active colitis and recovery states of ulcerative colitis. C57BL/6 mice were fed a basal diet supplemented with 2% asparagus or 0.025% rutin for 3 weeks. Colitis was induced by 2% dextran sodium sulfate in drinking water for 7 days. Asparagus diet was determined to contain higher antioxidant capacities than rutin diet through antioxidant assays. During active colitis, consumption of asparagus alleviated some clinical symptoms (stool consistency, stool blood, and spleen hypertrophy) of colitis. In recovery, asparagus-fed mice were improving in terms of regenerating crypts, surface epithelial, and goblet cells, potentially due to its rutin content. Overall, these findings advocate that asparagus can be therapeutic in treating symptoms during active colitis and recovery phases of ulcerative colitis. en_US
dc.language.iso en en_US
dc.subject Ulcerative colitis en_US
dc.subject Inflammatory bowel disease en_US
dc.subject Inflammation en_US
dc.subject Asparagus en_US
dc.subject Health en_US
dc.subject Diet en_US
dc.subject Antioxidant en_US
dc.subject Phenolic en_US
dc.subject Rutin en_US
dc.subject Quercetin en_US
dc.title The Effects of Cooked Whole Asparagus (Asparagus officinalis L.) and its Purified Bioactive, Rutin, on Symptoms of DSS-induced Acute Colitis and Recovery in C57BL/6 Mice en_US
dc.type Thesis en_US
dc.degree.programme Human Health and Nutritional Sciences en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Human Health and Nutritional Sciences en_US
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