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Author: Secord, David Cartwright
Abstract: A pathophysiological study of the visceral organism. A technique is described using the cat or dog for the isolation of the thoracic and abdominal viscera with an intact functioning circulatory system (visceral organism). The preparation requires artificial respiration and is attached to a blood reservoir while maintained in a constant temperature bath. In a series of preparations maintained at a mean blood pressure range of 40-45 mm. Hg. the lifespan was 6. 3 i 1. 3 hours. The gross and microscopic appearance of the viscera at necropsy were similar to the pathological changes reported in a variety of intact animals exposed to prolonged hypotension. Bacteriological examination showed a marked proliferation of common pathogens in the gastrointestinal tract and their invasion of the tissues. Preparations pretreated with antibiotics had a lifespan of 17 I 5. 8 hours but showed greater tissue damage terminally. Increasing the mean blood pressure range to 80-85 mm. Hg. prevented the tissue damage but contributed to the production of pulmonary edema and death of the visceral organisms at 7. 7 i 1. 8 hours. The use of antibiotic pretreatment failed to alter the end results. A marked leukopenia characterized by a neutropenia was observed to occur rapidly in all preparations. The leukopenia was maintained at a level of 1500 to 2500 W. B. C. per cu. mm. from the first hour after the preparation was made until its death. A rising blood urea nitrogen was observed as was a hyperglycemia followed by a slow decline in blood glucose levels to values approaching normal values at the time of death.
Description: A Thesis Presented to the Faculty of the Graduate School of the University of Toronto In Partial Fulfilment of the Requirements for the Degree of Master of Veterinary Science by David Cartwright Secord May, 1961
Date: 1961-05
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