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LITIGATION Of THE HEPATIC ARTERY, A BACTERIOLOGICAL, SEROLOGICAL AND SURGICAL STUDY

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Title: LITIGATION Of THE HEPATIC ARTERY, A BACTERIOLOGICAL, SEROLOGICAL AND SURGICAL STUDY
Author: Cobb, Leon M.
Abstract: The reason for the dual blood supply to the liver has intrigued experimenters for many years. One of the ways to study this system was to ligate either the arterial or the portal blood supply and note the effects. The early experimenters soon found that when the portal vein was ligated in the dog it rarely survived long enough to be removed from the operating table (54) (75). When they came to study ligation of the hepatic artery it mast have been with great surprise that they noted the animals dying, after a day or so, from an acute clostridial hepatitis. Could it be t en, that the arterial blood had a bacteriostatic activity which when curtailed by ligation of the hepatic artery allowed Clostridia to proliferate freely in the liver and cause the death of the host? Little light was thrown on this subject until 1949, when Markowitz, Rappaport and Scott (56) demonstrated that the lethal effect of ligation of the hepatic artery could be prevented by the administration of penicillin. Their interpretation of these findings was that the function of the hepatic artery is to prevent anaerobes normally contained in the liver from multiplying; once the hepatic artery is ligated the anaerobes will multiply unless controlled by penicillin.
Description: A Thesis Presented to the Faculty of the Graduate School of the University of Toronto in Partial fulfillment of the requirements for the degree of Doctor of Veterinary Science Leon M. Cobb 1960
URI: http://hdl.handle.net/10214/4891
Date: 1960
Rights: This work may be protected by copyright laws and is provided for educational and research purposes only. If you believe you are the rights holder and object to the University of Guelph's use of this document, please contact libair@uoguelph.ca.


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