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THE ABSORPTION AND DISTRIBUTION OF RADIOACTIVITY FOLLOWING APPLICATION OF C14-LABELLED DIETHYL-TOLUAMIDE TO THE SKIN OF GUINEA PIGS

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Title: THE ABSORPTION AND DISTRIBUTION OF RADIOACTIVITY FOLLOWING APPLICATION OF C14-LABELLED DIETHYL-TOLUAMIDE TO THE SKIN OF GUINEA PIGS
Author: Allan, John Rodney
Abstract: Research on the use of repellents to protect man and his domestic animals against biting arthropods was stimulated during the second World War. Since that time many compounds have been investigated in the search for a non-toxic, cosmetically acceptable, effective and long-lasting all-purpose repellent. The skin varies with the behaviour of the insects, the attractive properties of the host animal and the environmental conditions. The protection also depends on the rate of loss of repellent from the site of application as a result of evaporation, percutaneous absorption and chemical change (3). Kasman, Roadhouse and Wright (10) consider that the chief loss of repellency following application of repellents to the skin is caused by percutaneous absorption in many cases. The protection time of repellents applied to cloth (days or weeks) compared with the protection time given by the same compounds applied to skin (few hours) suggests the Importance of absorption or chemical breakdown of the repellents as factors limiting the effectiveness of these compounds applied to the skin of man and animals...
Description: A thesis submitted In partial fulfillment of the requirements for the Degree of Master of Veterinary Science to the School of Graduate Studies, University of Toronto, I960.
URI: http://hdl.handle.net/10214/4889
Date: 1960
Rights: This work may be protected by copyright laws and is provided for educational and research purposes only. If you believe you are the rights holder and object to the University of Guelph's use of this document, please contact libair@uoguelph.ca


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