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Author: Vesselinovitch, Stan
Abstract: The incidence of cancer has steadily increased during the past century especially in those countries that are industrially developed. Paralleling this increased industrial development with its diversification of industrial processes and products haa been the discovery of a mounting number and variety of exogenous carcinogens affecting various organs and tissues. These different environmental carcinogens, which form a part of both our natural and artificial environment, are practically the only known causes of cancer in man at the present time, and for this reason have considerable general significance. A knowledge of the exogenous causes of cancer is essential for the institution of rational and effective measures of prevention and control of the disease. For that reason biological testing of substances for their carcinogenic properties represents a very important step in the prevention of cancers of exogenous origin. Moreover a better knowledge of the mechanism involved in the chemical induction of cancers may contribute to a fuller comprehension of this disease. The use of chemically defined carcinogens with inbred strains of mice in the experimental induction of cancer constitutes an excellent tool for the study of the underlying mechanism of carcinogenesis and the factors that May modify this process. A better understanding of these factors not only broadens our knowledge of the basic phenomena governing carcinogenesis but also may prove useful in providing more sensitive methods for the testing of suspected carcinogens. With these general objectives in view, the experiments presented here were undertaken.
Description: A Thesis Presented to the Faculty of the Graduate School of the University of Toronto in Partial Fulfilment of the Requirements for the Degree of Master of Veterinary Science 1957.
Date: 1957
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