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Characterizing the Interspecific Nucleotide Diversity and Rates of Evolution of Ryanodine Receptors

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dc.contributor.advisor Griswold, Cortland
dc.contributor.author McKay, Patrick
dc.date.accessioned 2012-12-13T17:56:11Z
dc.date.available 2012-12-13T17:56:11Z
dc.date.copyright 2012-12
dc.date.created 2012-11-15
dc.date.issued 2012-12-13
dc.identifier.uri http://hdl.handle.net/10214/4880
dc.description.abstract This thesis is an investigation of the evolution of Ryanodine receptor (RyR) genes. In this study, I characterized the interspecific evolution of RyRs by estimating their nucleotide diversity and dN/dS ratios to better understand their molecular evolution. In the first part, I found evidence suggesting that divergent regions undergo positive selection and that mutation cluster regions undergo purifying selection. In the second part, I found evidence suggesting that RyRs are under strong purifying selection. In the third part, I found evidence suggesting that RyR1a and RyR1b in fish may have undergone neofunctionalization. In the fourth part, I found evidence suggesting that RyR2 and RyR3 and RyR3 and DHPR have correlated rates of evolution. I propose that this is may be a result of compensatory evolution between RyRs. I tested for compensatory function by simulating mutations via a physiological model of RyR function, but did not find evidence for compensation. en_US
dc.description.sponsorship National Science and Engineering Research Council, Canadian Foundation for Innovation en_US
dc.language.iso en en_US
dc.subject nucleotide diversity en_US
dc.subject divergent regions en_US
dc.subject mutation cluster regions en_US
dc.subject dN/dS en_US
dc.subject purifying selection en_US
dc.subject neofunctionalization en_US
dc.subject correlated evolution en_US
dc.subject compensation en_US
dc.subject compensatory mutations en_US
dc.subject RyR en_US
dc.subject DHPR en_US
dc.subject Ryanodine receptor en_US
dc.subject rate of evolution en_US
dc.subject evolution en_US
dc.subject RyR1 en_US
dc.subject RyR2 en_US
dc.subject RyR3 en_US
dc.subject RyR1a en_US
dc.subject RyR1b en_US
dc.title Characterizing the Interspecific Nucleotide Diversity and Rates of Evolution of Ryanodine Receptors en_US
dc.type Thesis en_US
dc.degree.programme Integrative Biology en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Integrative Biology en_US


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