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EVOLUTIONARY ANALYSIS AND GENETIC MAPPING OF NEUROPEPTIDE Y (NPY) RECEPTORS IN RAINBOW TROUT (ONCORHYNCHUS MYKISS) AND ARCTIC CHARR (SALVELINUS ALPINUS)

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dc.contributor.advisor Danzmann, Roy
dc.contributor.advisor Ferguson, Moira
dc.contributor.author Goldt, Aaron
dc.date.accessioned 2012-10-03T19:44:53Z
dc.date.available 2012-10-03T19:44:53Z
dc.date.copyright 2012-10
dc.date.created 2012-10-01
dc.date.issued 2012-10-03
dc.identifier.uri http://hdl.handle.net/10214/4048
dc.description.abstract Neuropeptide Y (NPY) receptors are an important multifunctional gene family found in vertebrates characterized by a complex evolutionary history of gene duplication and loss. I genetically mapped and sequenced the NPY receptors in rainbow trout (Oncorhynchus mykiss) and Arctic charr (Salvelinus alpinus) to examine the fate of this receptor family following the whole genome duplication in the salmonid ancestor. Based on receptors present in model teleosts, the Y1, Y2, Y4, Y7, Y8a and Y8b receptors were predicted to occur in the salmonid genome. Single copies of Y2, Y7 and Y8b and a tandem duplication of Y8a were detected in both rainbow trout and Arctic charr. Bayesian phylogenetic analysis strongly supports the model of NPY receptor evolution through multiple duplication events. The absence of multiple receptor subtypes and the presence of a tandem duplicate were unexpected but fall within patterns observed from previous duplication events. en_US
dc.description.sponsorship NSERC en_US
dc.language.iso en en_US
dc.rights.uri http://creativecommons.org/licenses/by-sa/2.5/ca/ *
dc.subject rainbow trout (Oncorhynchus mykiss) en_US
dc.subject Arctic charr (Salvelinus alpinus) en_US
dc.subject gene duplication en_US
dc.subject neuropeptide Y (NPY) en_US
dc.title EVOLUTIONARY ANALYSIS AND GENETIC MAPPING OF NEUROPEPTIDE Y (NPY) RECEPTORS IN RAINBOW TROUT (ONCORHYNCHUS MYKISS) AND ARCTIC CHARR (SALVELINUS ALPINUS) en_US
dc.type Thesis en_US
dc.degree.programme Integrative Biology en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Integrative Biology en_US
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Supplementary file 1. NPYR final alignment.fas 109.1Kb Text file View/Open Supplementary file 1
Supplementary f ... Y8b sequence alignment.fas 43.13Kb Text file View/Open Supplementary file 2
Goldt_Aaron_201209_Msc.pdf 1.180Mb PDF View/Open main article

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