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EVOLUTIONARY ANALYSIS AND GENETIC MAPPING OF NEUROPEPTIDE Y (NPY) RECEPTORS IN RAINBOW TROUT (ONCORHYNCHUS MYKISS) AND ARCTIC CHARR (SALVELINUS ALPINUS)

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Title: EVOLUTIONARY ANALYSIS AND GENETIC MAPPING OF NEUROPEPTIDE Y (NPY) RECEPTORS IN RAINBOW TROUT (ONCORHYNCHUS MYKISS) AND ARCTIC CHARR (SALVELINUS ALPINUS)
Author: Goldt, Aaron
Department: Department of Integrative Biology
Program: Integrative Biology
Advisor: Danzmann, RoyFerguson, Moira
Abstract: Neuropeptide Y (NPY) receptors are an important multifunctional gene family found in vertebrates characterized by a complex evolutionary history of gene duplication and loss. I genetically mapped and sequenced the NPY receptors in rainbow trout (Oncorhynchus mykiss) and Arctic charr (Salvelinus alpinus) to examine the fate of this receptor family following the whole genome duplication in the salmonid ancestor. Based on receptors present in model teleosts, the Y1, Y2, Y4, Y7, Y8a and Y8b receptors were predicted to occur in the salmonid genome. Single copies of Y2, Y7 and Y8b and a tandem duplication of Y8a were detected in both rainbow trout and Arctic charr. Bayesian phylogenetic analysis strongly supports the model of NPY receptor evolution through multiple duplication events. The absence of multiple receptor subtypes and the presence of a tandem duplicate were unexpected but fall within patterns observed from previous duplication events.
URI: http://hdl.handle.net/10214/4048
Date: 2012-10


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Supplementary file 1. NPYR final alignment.fas 109.1Kb Text file View/Open Supplementary file 1
Supplementary f ... Y8b sequence alignment.fas 43.13Kb Text file View/Open Supplementary file 2
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