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Role of an Isoform of Zhangfei/CREBZF in the Apoptotic Pathway of the Unfolded Protein Response

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dc.contributor.advisor Lu, Ray Yip, Wan Kong 2012-09-13T20:56:45Z 2012-09-13T20:56:45Z 2012-09 2012-08-27 2012-09-13
dc.description.abstract The unfolded protein response (UPR) is a well conserved mechanism in eukaryotes that protects organisms from the damaging effects of endoplasmic reticulum (ER) stresses. Activation of the UPR will lead to two outcomes. It first attempts to restore cellular functions by enhancing protein folding capacity, inhibiting protein synthesis and promoting degradation of harmful proteins (the pro-survival pathway). However, if the stressful conditions are prolonged or severe, apoptosis will be induced (the pro-apoptotic pathway). The present study suggests that an isoform of the cellular protein Zhangfei (ZF, CREBZF) is linked to the pro-apoptotic pathway in the UPR by using DNA, protein and cell viability analyses. This isoform is known as the short-tail ZF (stZF). We demonstrated that stZF can be induced by prolonged ER stress. The protein of stZF is stable under ER stress and it has the ability to promote programmed cell death in the early stage of apoptosis through the induction of CHOP, a protein that plays a key role in the pro-apoptotic pathway of the UPR. en_US
dc.language.iso en en_US
dc.subject Apoptosis en_US
dc.subject CREBZF en_US
dc.subject Zhangfei en_US
dc.subject Unfolded Protein Response en_US
dc.subject ER stress en_US
dc.subject Tunicamycin en_US
dc.title Role of an Isoform of Zhangfei/CREBZF in the Apoptotic Pathway of the Unfolded Protein Response en_US
dc.type Thesis en_US Molecular and Cellular Biology en_US Master of Science en_US Department of Molecular and Cellular Biology en_US
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