Main content

The influence of chronic, systemic inflammation in the progression of epithelial ovarian cancer

Show simple item record

dc.contributor.advisor Petrik, Jim Kerr, Amanda 2012-08-28T15:32:27Z 2012-08-28T15:32:27Z 2012-08 2012-08-20 2012-08-28
dc.description.abstract Epidemiological studies have described a link between chronic inflammatory conditions, such as diabetes or obesity, and EOC suggesting that systemic inflammation may increase the risk of the disease. The purpose of this study was to identify the impact of prolonged exposure to low-grade inflammation on EOC tumorigenicity. We hypothesized that exposure to this inflammation would accelerate ovarian tumor growth. In vitro, normal and transformed ovarian epithelial cells had limited responsiveness to inflammatory cytokines. In vivo, LPS-induced low-grade chronic systemic inflammation accelerated EOC progression primarily through enhanced angiogenesis. Evaluation of the relationships between chronic systemic inflammation and EOC may provide a role for anti-inflammatory treatment in combinational EOC therapies. Additionally, as the rate of metabolic disorders increases in the Western world the results from this work may facilitate the advancement of complimentary therapeutic interventions for other cancers that are influenced by inflammation. en_US
dc.language.iso en en_US
dc.subject ovarian cancer en_US
dc.subject inflammation en_US
dc.subject cancer en_US
dc.subject ovarian surface epithelium en_US
dc.title The influence of chronic, systemic inflammation in the progression of epithelial ovarian cancer en_US
dc.type Thesis en_US Biomedical Sciences en_US Master of Science en_US Department of Biomedical Sciences en_US
dc.rights.license All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.

Files in this item

Files Size Format View
Kerr_-_Final_thesis_August_24.pdf 8.671Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record