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Associations among neutrophil function, metabolic indicators, and reproductive health in dairy cows

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dc.contributor.advisor LeBlanc, Stephen
dc.contributor.author Wittrock, Julie
dc.date.accessioned 2012-05-10T19:18:39Z
dc.date.available 2012-05-10T19:18:39Z
dc.date.copyright 2012-04
dc.date.created 2012-04-25
dc.date.issued 2012-05-10
dc.identifier.uri http://hdl.handle.net/10214/3611
dc.description.abstract This thesis is an investigation of the interactions of insulin resistance (IR), metabolic markers, neutrophil function, and reproductive health in peripartum dairy cows, including the evaluation of a hand-held glucometer for diagnosis of IR. The neutrophil functions of interest were oxidative burst and phagocytosis capacity, and reproductive diseases were endometritis and cervicitis. A total of 81 Holstein cows were enrolled 3 wk prior to expected calving date from November 2010 until October 2011, and were followed until 5 wk postpartum. Known markers of IR, neutrophil function, and disease were monitored through this period. The hand-held glucometer was identified as a useful alternative to laboratory measurements of glucose. Markers of IR influenced phagocytosis capacity and reproductive disease. High haptoglobin concentrations were associated with increased risk of reproductive disease and diminished oxidative burst function. Metabolically related inhibition of neutrophil function may be important in development of reproductive disease. en_US
dc.description.sponsorship National Sciences and Engineering Research Council of Canada, Ontario Graduate Scholarship Program en_US
dc.language.iso en en_US
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/2.5/ca/ *
dc.subject dairy cow en_US
dc.subject immune function en_US
dc.subject reproductive health en_US
dc.subject insulin resistance en_US
dc.subject metabolic indicators en_US
dc.subject endometritis en_US
dc.subject cervicitis en_US
dc.subject oxidative burst en_US
dc.subject phagocytosis en_US
dc.subject neutrophil en_US
dc.title Associations among neutrophil function, metabolic indicators, and reproductive health in dairy cows en_US
dc.type Thesis en_US
dc.degree.programme Population Medicine en_US
dc.degree.name Master of Science en_US
dc.degree.department Population Medicine en_US
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http://creativecommons.org/licenses/by-nc-nd/2.5/ca/ Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by-nc-nd/2.5/ca/