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Investigating the Plasmid Uptake of Salmonella enterica in the Presence of Gastrointestinal Stressors

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Title: Investigating the Plasmid Uptake of Salmonella enterica in the Presence of Gastrointestinal Stressors
Author: May, Nikola
Department: Department of Pathobiology
Program: Pathobiology
Advisor: Ricker, Nicole
Abstract: The human gastrointestinal tract has been described as a “mixing pot” for dissemination of genetic elements due to the variety of organisms in the intrinsic gut microbiome and its ability to act as a genetic reservoir. Genes are often transferred via conjugation but few studies to date have examined the frequency of plasmid transfer in the environmental conditions of the gastrointestinal tract. Salmonella enterica carries many different families of plasmids, which have varying transmission dynamics. We observed how S. enterica plasmid transfer dynamics are affected by environmental factors (including pH, bile acids, the presence of a microbiota) consistent with transit through the gastrointestinal (GI) tract. We determined that S. enterica’s response to stress, and S. enterica's ability as a recipient, were strain specific. Furthermore, the majority of S. enterica strains studied were more efficient recipients after an acid-shock.
URI: https://hdl.handle.net/10214/26887
Date: 2022-04
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