Main content

Investigating the Role of Blood Flow and Muscle Contractions in Post-Glucose Glycemic Control and Vascular Function

Show full item record

Title: Investigating the Role of Blood Flow and Muscle Contractions in Post-Glucose Glycemic Control and Vascular Function
Author: Cohen, Jeremy
Department: Department of Human Health and Nutritional Sciences
Program: Human Health and Nutritional Sciences
Advisor: Burr, Jamie
Abstract: Post-prandial glycemic and vascular function impairments are ameliorated by acute exercise. Blood flow restriction (BFR) and electric muscle stimulation (EMS) offer similar characteristics, inducing hyperemia and preferential glucose oxidation. In 13 active participants (27±3yr, 7 female) we measured post-glucose (oral 100g) glycemic, cardiometabolic and vascular function measures over 120min following four interventions: BFR, EMS, BFR+EMS or Control. Glycemic and insulinemic responses were not different between interventions (both P>0.15). However, BFR+EMS produced 'interval-like' effects on oxygen consumption, carbohydrate oxidation and muscle oxygenation relative to all interventions (all P<0.01). Cacrovascular function was significantly reduced 60min post-glucose and recovered at 120min (P<0.001). Microvascular measures lacked meaningful differences. Leg blood flow and vascular conductance increased with BFR only 60min post-intervention (P=0.02). BFR+EMS did not preferentially improve post-glucose metabolic or vascular function, despite causing intended 'interval-like' effects on markers of glycemic and vascular regulation. Future study should investigate BFR+EMS in clinically sensitive populations.
URI: https://hdl.handle.net/10214/26592
Date: 2021-12
Terms of Use: All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.


Files in this item

Files Size Format View Description
Cohen_Jeremy_202112_MSc.pdf 1.621Mb PDF View/Open Thesis

This item appears in the following Collection(s)

Show full item record