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Functional Changes to the Modulation of alpha4beta2* Nicotinic Acetylcholine Receptors During Postnatal Maturation

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dc.contributor.advisor Bailey, Craig
dc.contributor.author Hewitson, Elizabeth
dc.date.accessioned 2021-10-01T20:16:48Z
dc.date.available 2021-10-01T20:16:48Z
dc.date.copyright 2021-09
dc.date.created 2021-09-24
dc.identifier.uri https://hdl.handle.net/10214/26499
dc.description.abstract Acetylcholine (ACh) initiates an excitatory response at nicotinic acetylcholine receptors (nAChRs), although this activity may be modulated by mechanisms that alter receptor function. This thesis investigates whole-cell electrophysiological properties of pyramidal neurons expressing α4β2* nAChRs within brain slices of male and female mice aged young postnatal (P) 15-20 and adult P 80-120, corresponding ACh-driven currents, and how these currents are modulated by nicotine, allopregnanolone (ALLO) and galantamine. nAChR desensitization by nicotine was greater in young mice and this result was driven by an effect of postnatal age in males only. In contrast, ALLO inhibited nAChR function to a similar degree at each age. Galantamine potentiated nAChR function to a similar degree at each age, although this potentiation was significantly greater in females. Results from this study suggest that distinct factors are involved in each type of receptor modulation, which are differentially altered during postnatal maturation and across biological sex. en_US
dc.description.sponsorship Funding was provided by the Natural Sciences and Engineering Research Council (NSERC), Ontario Veterinary College Scholarship and Canada Foundation for Innovation en_US
dc.language.iso en en_US
dc.publisher University of Guelph en_US
dc.subject Acetylcholine en_US
dc.subject Nicotinic Acetylcholine Receptor en_US
dc.subject Allopregnanolone en_US
dc.subject Galantamine en_US
dc.subject Nicotine en_US
dc.subject Development en_US
dc.subject Pharmacology en_US
dc.subject Modulation en_US
dc.title Functional Changes to the Modulation of alpha4beta2* Nicotinic Acetylcholine Receptors During Postnatal Maturation en_US
dc.type Thesis en_US
dc.degree.programme Biomedical Sciences en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Biomedical Sciences en_US
dc.rights.license All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.degree.grantor University of Guelph en_US


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