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The Effects of Diet and Chronic Exercise on Skeletal Muscle Ghrelin Response

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dc.contributor.advisor Dyck, David Lovell, Andrew 2021-09-17T16:25:40Z 2021-09-17T16:25:40Z 2021-09 2021-08-25
dc.description.abstract Ghrelin is an orexigenic hormone that was initially believed to only play a role in appetite regulation. Recently ghrelin has been shown to stimulate fatty acid oxidation and preserve insulin response in muscle in conditions of elevated fatty acid availability. These effects are lost following chronic high-fat feeding in skeletal muscle. Whether ghrelin’s peripheral effects are altered with exercise has not been examined. We found that ghrelin response was present in skeletal muscle following 5 days of high, or low-fat feeding, but lost following 6 weeks of a high-fat diet. Exercise was able recover ghrelin mediated increases in fatty acid oxidation and the preservation of insulin stimulated glucose uptake. The preservation of ghrelin response was accompanied by increases in CRF-2R content, the purported receptor for UnAG in skeletal muscle. These findings suggest that exercise is able to prevent the development of skeletal muscle ghrelin resistance in high-fat fed rats. en_US
dc.language.iso en en_US
dc.publisher University of Guelph en_US
dc.subject Metabolism en_US
dc.subject Skeletal Muscle en_US
dc.subject Ghrelin en_US
dc.subject Animal en_US
dc.subject Adipose Tissue en_US
dc.subject Exercise en_US
dc.subject physiology en_US
dc.subject Training en_US
dc.title The Effects of Diet and Chronic Exercise on Skeletal Muscle Ghrelin Response en_US
dc.type Thesis en_US Human Health and Nutritional Sciences en_US Master of Science en_US Department of Human Health and Nutritional Sciences en_US
dc.rights.license All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated. University of Guelph en_US

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