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Investigating a Novel Approach to Prostate Tumour Treatment in Dogs

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dc.contributor.advisor Mutsaers, Anthony McKenna, Charly 2021-09-15T11:54:32Z 2021-09 2021-09-08
dc.description.abstract Prostate cancer (PC) is the most frequent cancer in men but uncommon in dogs. In veterinary medicine, there is no consensus for standard-of-care treatment of PC, even combined therapies offer limited success with a guarded prognosis (≤ 1 year). As urinary obstruction is a frequent reason for euthanasia in dogs with PC, better local tumour control is warranted. Gold nanoparticles (AuNP) have potential for biomedical applications and can be produced via "green synthesis" incorporating plant nutraceuticals. In a pilot study of 4 dogs (3 purpose-bred and 1 diagnosed with PC), we demonstrated that green synthesized AuNP can be safely delivered to the prostate gland via a minimally invasive technique and that functionalized AuNP are generally well-tolerated. While in the early stages, our results suggest that this novel approach may be worthy of further research and development with potential future clinical applications for both dog and human patients with prostate tumours. en_US
dc.description.sponsorship Ontario Veterinary College Pet Trust; Telus Ride for Dad en_US
dc.language.iso en en_US
dc.publisher University of Guelph en_US
dc.subject Prostate cancer en_US
dc.subject dogs en_US
dc.subject Gold nanoparticles en_US
dc.subject prostate tumours en_US
dc.subject standard-of-care treatment en_US
dc.title Investigating a Novel Approach to Prostate Tumour Treatment in Dogs en_US
dc.type Thesis en_US Biomedical Sciences en_US Master of Science en_US Department of Biomedical Sciences en_US
dc.description.embargo 2022-09-01
dc.rights.license All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated. University of Guelph en_US

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