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Estradiol Induces Dose-, Time-, and Region-Specific Changes to Activity-Regulated Cytoskeleton-Associated Protein (Arc) in the Mouse Brain

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dc.contributor.advisor Choleris, Elena
dc.contributor.advisor Lalonde, Jasmin
dc.contributor.author Rizwan, Yamna
dc.date.accessioned 2021-09-14T19:57:32Z
dc.date.available 2021-09-14T19:57:32Z
dc.date.copyright 2021-09
dc.date.created 2021-09-13
dc.identifier.uri https://hdl.handle.net/10214/26417
dc.description.abstract Estrogens have been implicated extensively in learning, memory, dendritic spinogenesis, and synaptic plasticity. The molecular pathways underlying estrogens’ rapid, nongenomic actions are not well understood, however protein translation of dendritically-localized mRNA transcripts may be a possible mechanism of action. The Activity-regulated cytoskeleton-association protein (Arc) has emerged as a strong candidate for the mediation of these effects. Here, we present findings from mouse in vivo and primary cortical cell culture models demonstrating Arc’s dynamic regulation following stimulation by 17beta-estradiol (E2) within 15- to 40-minutes of treatment. Further, we show that E2 induces a differential localization of dendritic Arc dependent on the length of time that follows E2 treatment. In sum, these data suggest a novel role for Arc acting within a mechanism of E2-facilitated neuronal actions that is dose-, time-, and dendritic region-dependent, advocating for a multi-mechanism approach to studying Arc’s involvement in estrogenic short-term memory facilitation within the mouse brain. en_US
dc.language.iso en en_US
dc.publisher University of Guelph en_US
dc.subject nongenomic estrogenic molecular mechanisms en_US
dc.subject estrogens en_US
dc.subject estradiol en_US
dc.subject learning and memory en_US
dc.subject activity-regulated cytoskeleton-associated protein en_US
dc.subject Arc en_US
dc.title Estradiol Induces Dose-, Time-, and Region-Specific Changes to Activity-Regulated Cytoskeleton-Associated Protein (Arc) in the Mouse Brain en_US
dc.type Thesis en_US
dc.degree.programme Neuroscience en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Psychology en_US
dc.rights.license All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.degree.grantor University of Guelph en_US


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