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The Rapid Effects of Estrogens in the Medial Prefrontal Cortex of Female Mice and their role in Social and Object Recognition

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dc.contributor.advisor Choleris, Elena
dc.contributor.author Kachmarchuk, Oksana
dc.date.accessioned 2021-09-10T21:28:09Z
dc.date.available 2021-09-10T21:28:09Z
dc.date.copyright 2021-09
dc.date.created 2021-09-08
dc.identifier.uri https://hdl.handle.net/10214/26393
dc.description.abstract A critical component of social cognition is distinguishing between species conspecifics, known as social recognition (SR). SR is mediated by the interaction of several brain regions within the social brain and various neurohormones, including estradiol (E2). One brain region within the social brain that is also likely to mediate SR rapidly is the medial prefrontal cortex (mPFC). Therefore, our first study aimed to determine if E2 in the mPFC rapidly mediates SR. In this project, female mice were infused with E2 15 minutes before taking part in a rapid social recognition paradigm. Afterwards, since the mPFC also mediates several other forms of memory, a second experiment was conducted to assess if E2 in the mPFC also has a role in rapidly mediating object recognition (OR). Results for the SR paradigm demonstrated that E2 infused into the mPFC rapidly facilitates SR, but not OR memory. Overall, this research provides novel information on the effects of estrogens within the social brain. en_US
dc.language.iso en en_US
dc.publisher University of Guelph en_US
dc.subject social recognition en_US
dc.subject medial prefrontal cortex en_US
dc.subject object recognition en_US
dc.subject estradiol en_US
dc.subject estrogens en_US
dc.title The Rapid Effects of Estrogens in the Medial Prefrontal Cortex of Female Mice and their role in Social and Object Recognition en_US
dc.type Thesis en_US
dc.degree.programme Neuroscience en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Psychology en_US
dc.rights.license All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.degree.grantor University of Guelph en_US


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