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An Investigation of the Classification, Seasonality, and Genotype Diversity of Rotavirus in Swine Populations in Canada

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Title: An Investigation of the Classification, Seasonality, and Genotype Diversity of Rotavirus in Swine Populations in Canada
Author: Tran, Hoc
Department: Department of Population Medicine
Program: Population Medicine
Advisor: Poljak, Zvonimir
Abstract: Rotavirus is an important cause of acute gastroenteritis affecting swine globally and this thesis examined important characteristics of rotavirus in swine populations in Canada to enhance current disease control practices. A classification tool was developed using machine learning alongside alignment-based methodology for dual classification of group A rotavirus genotypes and demonstrated strong performance. Seasonality of group A, B, and C rotaviruses was explored through descriptive analysis, time-series decomposition, and statistical analysis of surveillance data obtained from a diagnostic laboratory and was identified to not be present in Canada between 2016-2020. Genotype diversity of group A, B and C rotaviruses was investigated between 2011-2021 and no major shifts in the patterns of circulating genotypes were identified in group A and B rotaviruses, although proportion of laboratory positivity for genotype G6 of group C rotaviruses showed an increasing trend when evaluated descriptively on an annual basis.
URI: https://hdl.handle.net/10214/26369
Date: 2021-09
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Embargoed Until: 2022-08-31


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