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Evaluation of Pain-Related Facial Expressions and Behaviour to Refine Perioperative Care of Cynomolgus Macaques

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dc.contributor.advisor Turner, Patricia
dc.contributor.advisor Wood, Geoffrey Paterson, Emilie 2021-08-27T15:08:21Z 2021-08-19 2021-08-19
dc.description.abstract Research primates may experience pain due to veterinary or experimental procedures and effective perioperative care is essential from a welfare and scientific standpoint. The aim of this work was to (1) create and validate a macaque grimace scale, and (2) assess analgesic therapeutic efficacy during the night. Video recording of cynomolgus macaques (Macaca fascicularis) (n=43) pre- and post-surgery was conducted, 1940 images were scored by observers (n=12), and detailed day (111 h) and night (224 h) behaviours were assessed. A novel grimace tool was developed and results indicated overall good inter-rater reliability (ICCaverage meanSD: 0.670.28). Construct/criterion validity was established as grimace scores increased significantly up to 17 h post-op compared to baseline (p<0.001), and behavioural trends correlated with grimace scores (rho=0.22-0.35, p<0.001). General and pain-associated night time behaviours significantly differed from baseline (p<0.05), but not social behaviour. These findings are important to refine perioperative care of research primates. en_US
dc.description.sponsorship Natural Sciences and Engineering Research Council of Canada; Ontario Veterinary College en_US
dc.language.iso en en_US
dc.publisher University of Guelph en_US
dc.subject Primate en_US
dc.subject Pain en_US
dc.subject Behaviour en_US
dc.subject Cynomolgus macaque en_US
dc.subject Facial grimace scale en_US
dc.subject Animal welfare en_US
dc.title Evaluation of Pain-Related Facial Expressions and Behaviour to Refine Perioperative Care of Cynomolgus Macaques en_US
dc.type Thesis en_US Pathobiology en_US Master of Science en_US Department of Pathobiology en_US
dc.description.embargo 2022-08-19
dc.rights.license All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated. University of Guelph en_US

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