Main content

Evaluation of Pain-Related Facial Expressions and Behaviour to Refine Perioperative Care of Cynomolgus Macaques

Show full item record

Title: Evaluation of Pain-Related Facial Expressions and Behaviour to Refine Perioperative Care of Cynomolgus Macaques
Author: Paterson, Emilie
Department: Department of Pathobiology
Program: Pathobiology
Advisor: Turner, PatriciaWood, Geoffrey
Abstract: Research primates may experience pain due to veterinary or experimental procedures and effective perioperative care is essential from a welfare and scientific standpoint. The aim of this work was to (1) create and validate a macaque grimace scale, and (2) assess analgesic therapeutic efficacy during the night. Video recording of cynomolgus macaques (Macaca fascicularis) (n=43) pre- and post-surgery was conducted, 1940 images were scored by observers (n=12), and detailed day (111 h) and night (224 h) behaviours were assessed. A novel grimace tool was developed and results indicated overall good inter-rater reliability (ICCaverage meanSD: 0.670.28). Construct/criterion validity was established as grimace scores increased significantly up to 17 h post-op compared to baseline (p<0.001), and behavioural trends correlated with grimace scores (rho=0.22-0.35, p<0.001). General and pain-associated night time behaviours significantly differed from baseline (p<0.05), but not social behaviour. These findings are important to refine perioperative care of research primates.
URI: https://hdl.handle.net/10214/26310
Date: 2021-08-19
Terms of Use: All items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
Embargoed Until: 2022-08-19


Files in this item

Files Size Format View Description
Paterson_Emilie_202108_MSc.pdf 7.734Mb PDF View/Open Third thesis submission

This item appears in the following Collection(s)

Show full item record

The library is committed to ensuring that members of our user community with disabilities have equal access to our services and resources and that their dignity and independence is always respected. If you encounter a barrier and/or need an alternate format, please fill out our Library Print and Multimedia Alternate-Format Request Form. Contact us if you’d like to provide feedback: lib.a11y@uoguelph.ca  (email address)