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Targeting the endocannabinoid system as a novel anti-cancer therapy for urothelial carcinoma

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Title: Targeting the endocannabinoid system as a novel anti-cancer therapy for urothelial carcinoma
Author: Inkol, Jordon
Department: Department of Clinical Studies
Program: Clinical Studies
Advisor: Mutsaers, Anthony
Abstract: Urothelial carcinoma (UC) is the most common form of bladder cancer in both humans and dogs. Treatment options for UC often have variable response rates with only 50% of patients responding long term. Evidence suggests cannabinoids, both endogenous and plant based, are potent anti-cancer therapies with potential to enhance current treatments. However, their potential benefits have not been explored in UC. It was determined that cannabidiol (CBD), a phytocannabinoid, synergizes chemotherapy treatment. Further, combination with radiation therapy demonstrated CBD’s potential to radiosensitize UC cell lines. Finally, inhibition of MAGL, a metabolic enzyme in the endocannabidiome, impaired migration and invasion conferring a less aggressive phenotype. These findings suggest that cannabinoids may be novel anti-cancer therapies for both canine and human UC. Further studies are required to confirm these results in more complex models.
URI: https://hdl.handle.net/10214/25936
Date: 2021-07
Rights: Attribution-ShareAlike 4.0 International
Embargoed Until: 2022-02-02


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Attribution-ShareAlike 4.0 International Except where otherwise noted, this item's license is described as Attribution-ShareAlike 4.0 International