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An investigation of post-weaning diarrhea control strategies and enterotoxigenic Escherichia coli challenge trial methodology

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Title: An investigation of post-weaning diarrhea control strategies and enterotoxigenic Escherichia coli challenge trial methodology
Author: Goodman, Michelle-Rose
Department: Department of Population Medicine
Program: Population Medicine
Advisor: Friendship, RobertFarzan, Abdolvahab
Abstract: Strategies for preventing post-weaning diarrhea to enhance growth and health of nursery pigs were examined using clinical on-farm trials, and in addition, experimental E. coli challenge methodologies were synthesized and compared. Two clinical trials were conducted to examine the effectiveness of a live oral vaccine. Diarrhea was more prevalent in vaccinated pigs in 1 of 2 trials (P < 0.05), but growth was similar between vaccinated and non-vaccinated pigs (P > 0.05). The use of diets containing alternative protein sources compared to soybean meal was also evaluated. Faster growth and less diarrhea was observed in nursery pigs fed complex diets containing alternative proteins compared to diets with higher levels of soy. Lastly, a scoping review of E. coli experimental challenge studies was conducted. Factors that were examined included; pig age, bacterial strain, dose and method of administration. Both on-farm and experimental challenge studies can be useful in evaluating control measures.
URI: https://hdl.handle.net/10214/25930
Date: 2021-06
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